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Promethazine with codeine oral solution


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What is Promethazine with Codeine?

Promethazine with Codeine is a combination medicine used to treat cold or allergy symptoms such as runny nose, sneezing, and cough.

Promethazine with Codeine contains an opioid (narcotic) cough medicine, and may be habit-forming.

Promethazine with Codeine may also be used for purposes not listed in this medication guide.

Before taking this medicine

You should not use Promethazine with Codeine if you are allergic to codeine or promethazine, or if you have:

  • asthma or severe breathing problems;
  • a stomach or bowel obstruction(including paralytic ileus);
  • narrow-angle glaucoma; or
  • if you are unable to urinate.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, raagiline, selegiline, tranylcypromine, and others.

Promethazine with Codeine is not approved for use by anyone younger than 12 years old.

Usual Adult Dose for Promethazine Cough

Promethazine 6.25 mg/ Codeine 10 mg per 5 mL:
Average effective dose: 5 mL orally every 4 to 6 hours as needed
Maximum dose: 30 mL (promethazine 37.5 mg; codeine: 60 mg) in 24 hours

-Liquid preparations should be measured with an accurate milliliter measuring device.

Uses: Temporary relief of coughs and upper respiratory symptoms associated with allergy or the common cold.

Renal Dose Adjustments

Use with caution, especially in patients with severe renal impairment

Liver Dose Adjustments

Use with caution, especially in patients with severe hepatic impairment

Dose Adjustments

Elderly: Use with caution generally starting at the lower end of the dosing range.


This combination medication is used to treat symptoms caused by the common coldfluallergies, or other breathing illnesses (e.g., sinusitisbronchitis). Promethazine is an antihistamine that relieves watery eyes, itchy eyes/nose/throat, runny nose, and sneezing. Codeine is an opioid cough suppressant (antitussive) that affects a certain part of the brain, reducing the urge to cough.

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  1. Lisa Benson

    Am happy with this site. Different from others. It’s all good

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